DOXORRUBICINA LIPOSOMAL PEGILADA PDF

La doxorubicina es un agente de amplio espectro antitumoral. La doxorubicina liposomal pegilada inhibe el crecimiento celular del sarcoma de Kaposi tanto in vitro como in vivo. Los liposomas tienen una vida media aproximada de 55 horas en el humano. Una vez que los liposomas se distribuyen en el compartimento tisular, la doxorubicina encapsulada es liberada.

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Clin Breast Cancer. Pegylated liposomal doxorubicin in the treatment of breast cancer. Author information: 1 Charles A. However, the benefits of conventional doxorubicin in terms of antitumor activity are limited by its therapeutic index. Liposomal formulations were developed to increase the therapeutic index of conventional doxorubicin. Pegylated liposomal doxorubicin provides tumor-targeted efficacy without many of the toxicities associated with conventional doxorubicin, including myelosuppression, alopecia, nausea and vomiting, and most importantly, cardiac toxicity.

As a single agent, pegylated liposomal doxorubicin has demonstrated similar efficacy to that of conventional doxorubicin in patients with metastatic breast cancer. It has also demonstrated efficacy in combination with other agents or modalities, including cyclophosphamide, paclitaxel, docetaxel, gemcitabine, vinorelbine, and hyperthermia. Small studies also suggest a role for pegylated liposomal doxorubicin in the treatment of locally advanced breast cancer.

Preliminary results suggest that pegylated liposomal doxorubicin may be safely administered in combination with docetaxel and trastuzumab in patients with HER2-positive disease. Owing to its comparable efficacy and favorable safety profile, pegylated liposomal doxorubicin may be a useful alternative to conventional doxorubicin, as well as other agents commonly used in the treatment of breast cancer.

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